Preimplantation Genetic Diagnosis makes it possible to assess the genetic health of an embryo obtained in an In Vitro fertilization cycle prior to transferring to the Uterus. This unique method helps not only to select, the best embryos for transfer to the uterine cavity, but it also improves the efficiency of the treatment and reduces the potential for adverse pregnancy outcomes.
PGD is recommended to women over 38. The risk of a child developing chromosomal abnormalities, primarily Down syndrome, increases with the age of the parents. Preimplantation Genetic Diagnosis helps to mitigate this risk.
Women suffering from common miscarriage. If there were 3 or more pregnancy losses in the patient’s history (especially if the cause of such a loss was a chromosomal abnormality of the fetus), adding a Preimplantation Genetic Test to the treatment cycle will increase the chances of successful carrying the desired pregnancy.
Patients who have already undergone numerous IVF cycles. If the quality of embryos obtained in previous treatment cycles was high, but pregnancy did not occur after three or more embryo transfers, PGD can help to solve the problem.
Patients with hereditary diseases (genetic diseases or chromosomal changes). Such abnormalities can be transmitted to children and cause them physical and mental disabilities. However, during PGD, genes with “dangerous” combinations will be identified. This will make it possible to neutralize the genetic abnormalities of the parents and ensure the onset of a healthy pregnancy, even if the geneticist's prognosis is disappointing.
During diagnostics, a small part is taken from the embryo, which is studied using modern genetic methods. A properly performed biopsy is safe for the embryo and does not affect its further development.
Obtaining material for analysis can be carried out at different stages of embryo development. Thus, one blastomere can be biopted on the third day of cultivation. Then all the cells of the embryo have the ability to unlimited "regeneration" and the active division of the neighboring blastomeres quickly compensates the extraction of the cell. An alternative option is a biopsy on the fifth day of development, when the embryo has already formed a blastocyst. In this case, a piece of trophectoderm is taken for analysis, the layer of the embryonic cell, which in the future will form the shell of the fetus. The embryo blast, which is responsible for the formation of the fetus itself, remains intact.
Thus, whenever the biopsy is performed, it does not harm the embryos in any way, and this is confirmed by the high frequency of pregnancy in the cycles of treatment using PGD.
A variety of hereditary abnormalities requires more individual approach to PGD. The “Victoria” Reproductive Genetics Clinic will work over individual protocol of embryo genetic testing for carriers of genetic disorders. Therefore, preparing of the couple to the cycle of infertility treatment requires longer and meticulous arrangement.
In such cases, PGD can be an important alternative to prenatal diagnosis of pregnancy. If the fact of the inheritance of a genetic abnormality by a child is established during pregnancy, it becomes necessary to make difficult decisions. Genetic testing of embryos on the pre-implantation stage helps to avoid this difficult dilemma, but in such case even fertile couples should undergo a cycle of IVF treatment.
The “Victoria” clinic offers a wide range of genetic investigations. The clinic’s specialists will assist you with all information relevant to PGD procedure; will help in selection of a suitable individual plan of treatment.
Chief doctor of the clinic, obstetrics and gynecology doctor, fertility specialist, sonographer.
Deputy Chief Doctor, obstetrics and gynecology doctor, fertility specialist, sonographer
Head of Clinical Diagnostic Laboratory, geneticist
Obstetrician-gynecologist, fertility specialist, doctor of ultrasonic diagnostics, geneticist
Head of the Clinical Department, obstetrician-gynecologist, fertility specialist, sonographer